Nutrigenomic effects of edible bird’s nest on insulin signaling in ovariectomized rats
作者: Zhiping HouRozi MahmudMaznah IsmailMustapha Umar ImamDer Jiun OoiAini Ideris
作者单位: 1University Putra Malaysia
2Universiti Putra Malaysia
刊名: Drug Design, Development and Therapy, 2015, Vol.2015 (default), pp.4115-4125
来源数据库: Dove Journal
DOI: 10.2147/DDDT.S80743
原始语种摘要: Estrogen deficiency alters quality of life during menopause. Hormone replacement therapy (HRT) has been used to improve quality of life and prevent complications, but side effects limit its use. In this study, we evaluated the use of edible bird’s nest (EBN) for prevention of cardiometabolic problems in ovariectomy (OVX)-induced menopause in rats. Ovariectomized female rats were fed for 12 weeks with normal rat chow, EBN or estrogen and compared with normal non-ovariectomized rats. Metabolic indices (insulin, estrogen, superoxide dismutase, malondialdehyde, oral glucose tolerance test and lipid profile) were measured at the end of the experiment from serum and liver tissue homogenate, and transcriptional levels of hepatic insulin signaling genes were measured. The results showed that OVX...
全文获取路径: Dove 
影响因子:3.486 (2012)

  • insulin 胰岛素
  • ovariectomized 切除卵巢的
  • ovariectomy 卵巢摘除
  • prevention 妨碍
  • estrogen 雌激素
  • glucose 葡萄糖
  • indices 索引
  • menopause 绝经
  • homeostasis 体内平衡
  • homogenate 均质