Synthesis of three-arm block copolymer poly(lactic- co -glycolic acid)–poly(ethylene glycol) with oxalyl chloride and its application in hydrophobic drug delivery
作者: Xiaowei ZhuChao LiuJianwei DuanXiaoyu LiangXuanling LiHongfan SunDeling KongJing Yang
作者单位: 1Institute of Biomedical Engineering, Chinese Academy
刊名: International Journal of Nanomedicine, 2016, Vol.2016 (default), pp.6065-6077
来源数据库: Dove Journal
DOI: 10.2147/IJN.S119446
原始语种摘要: Purpose: Synthesis of star-shaped block copolymer with oxalyl chloride and preparation of micelle to assess the prospect for drug carrier applications.Methods: Three-arm star block copolymers poly(lactic-co-glycolic acid)-poly (ethylene glycol)( 3S-PLGA) was synthesized by ring-opening polymerization, then polyethylene glycol(PEG) as the hydrophilic block was linked to the terminal hydroxyl of 3S-PLGA with oxalyl chloride. Fourier-transform infrared(FTIR), gel permeation chromatography(GPC), hydrogen nuclear magnetic resonance spectrum(1H NMR) and differential scanning calorimetry(DSC) were employed to identify the structure and properties of 3S-PLGA-PEG. Rapamycin(RPM)-loaded micelles were prepared by solvent evaporation method and pyrene was used as the fluorescence probe to detect the...
全文获取路径: Dove  (合作)
影响因子:3.463 (2012)

  • glycolic acid 羟基乙酸
  • polyethylene 聚乙烯
  • micelle 胶束
  • copolymer 共聚物
  • lactic 乳汁的
  • oxalyl 草酰
  • chloride 氯化物
  • block 滑车
  • loaded 加负荷的
  • improved 改进