Development of PLGA-lipid nanoparticles with covalently conjugated indocyanine green as a versatile nanoplatform for tumor-targeted imaging and drug delivery
作者: Yu XinTie LiuChenlong Yang
作者单位: 1Beijing Tiantan Hospital
刊名: International Journal of Nanomedicine, 2016, Vol.2016 (default), pp.5807-5821
来源数据库: Dove Journal
DOI: 10.2147/IJN.S119999
原始语种摘要: We have prepared novel poly(D,L-lactide-co-glycolide) (PLGA) lipid nanoparticles that covalently conjugate folic acid (FA) as well as indocyanine green (ICG) and also encapsulate resveratrol (RSV) (FA-RIPNPs), which are developed for simultaneous anticancer drug targeted delivery and fluorescence imaging. The FA-RIPNPs, with an average particle size of (92.8 ± 2.1) nm, were prepared by a facile self-assembly as well as nanoprecipitation method and showed excellent stability and biocompatibility characteristics. The FA-RIPNPs exhibited a RSV encapsulation efficiency of approximately (65.6 ± 4.7)% and a maximum release ratio of (78.2 ± 4.1)% at pH 5.0 and 37 ºC. Confocal fluorescence images showed that FA-RIPNPs may facilitate a high cellular uptake via FA receptor-mediated endocytosis...
全文获取路径: Dove 
影响因子:3.463 (2012)

  • lipid 脂质
  • imaging 图像形成
  • targeted 对准目标的
  • tumor 肿胀
  • delivery 移交
  • glycolide 乙交酯
  • conjugated 共轭的
  • lactide 交酯
  • demonstrated 探明的储量
  • fluorescence 荧光