Nanomedicine engulfed by macrophages for targeted tumor therapy
作者: Yueqing GuSiwen LiSong FengLi DingYuxi LiuQiuyun ZhuZhiyu Qian
作者单位: 1China pharmaceutical university
刊名: International Journal of Nanomedicine, 2016, Vol.2016 (default), pp.4107-4124
来源数据库: Dove Journal
DOI: 10.2147/IJN.S110146
原始语种摘要: Macrophage, exhibiting high intrinsic accumulation and infiltration into tumor tissues, is a novel drug vehicle for directional drug delivery. However, the low drug loading capacity and the drug cytotoxicity to the cell vehicle have limited the application of macrophage on tumor therapy. In this study the different drugs involving small molecular and nanoparticle drugs were packed into intrinsic macrophage for investigation aimed to find a better way to overcome this limitation. Their drug loading capacity and cytotoxicity to the macrophages were firstly compared. Furthermore their phagocytic ratio, dynamic distributions and tumoricidal effects were also investigated. Results indicated that more lipid-soluble molecules and drug loading particles can be phagocytized by macrophages than...
全文获取路径: Dove 
影响因子:3.463 (2012)

  • macrophages 巨噬细胞
  • targeted 对准目标的
  • tumor 肿胀
  • cytotoxicity 细胞毒性
  • loading 加负载
  • immune 免疫的
  • pathway 轨道
  • phagocytic 吞噬细胞的
  • therapy 治疗
  • lipid 脂质