Total saponin of Dioscoreae hypoglaucae rhizoma ameliorates streptozotocin-induced diabetic nephropathy
作者: Zhaoqing MengChangrun GuoGang DingWenzhe HuangZhenzhong WangWei Xiao
作者单位: 1Jiangsu Kanion Pharmaceutical Co. Ltd
刊名: Drug Design, Development and Therapy, 2016, Vol.2016 (default), pp.799-810
来源数据库: Dove Journal
DOI: 10.2147/DDDT.S99670
原始语种摘要: Background: Diabetic nephropathy has become the most common cause of morbidity and mortality in diabetic patients. Therefore, there is an urgent need for more effective and safer drugs for use in this condition. Purpose: The aims of this study were to investigate the ameliorative effects of total saponin of Dioscoreae hypoglaucae rhizoma (TSD) on diabetic nephropathy and to explore the potential underlying mechanism(s). Methods: Rats with streptozotocin-induced diabetes were orally treated with TSD at 40, 80, and 160 mg/kg/day for 12 weeks. At the end of the treatment, blood, urine, and kidneys were collected for biochemical and histological examination. Results: The results demonstrated that TSD significantly decreased the fasting blood glucose, glycosylated hemoglobin, urinary protein,...
全文获取路径: Dove 
影响因子:3.486 (2012)

  • nephropathy 肾病
  • diabetic 糖尿病患者
  • streptozotocin 链脲佐菌素
  • rhizoma 根状茎
  • saponin 皂荚苷
  • induced 感应的
  • fasting 禁食
  • diabetes 糖尿病
  • glomerular 肾小球病
  • TSD Total System Down