Pharmacokinetics, distribution and anti-tumor efficacy of liposomal mitoxantrone modified with a luteinizing hormone-releasing hormone receptor-specific peptide
作者: Linhua ZhangYanqing RenYong WangYingna HeWei FengCunxian Song
作者单位: 1Institute of Biomedical Engineering, PUMC & CAMS
2Traditional Chinese Medicine Pharmacology Laboratory
3Hebei TCM Formula Granule Engineering & Technology Research Center
4biomaterial and drug delivery lab
刊名: International Journal of Nanomedicine, 2018, Vol.2018 (default), pp.1097-1105
来源数据库: Dove Journal
DOI: 10.2147/IJN.S150512
原始语种摘要: In a previous study, we developed a novel luteinizing hormone-releasing hormone (LHRH) receptor-targeted liposome. The aim of this study was to further assess the pharmacokinetics, biodistribution and anti-tumor efficacy of LHRH receptor-targeted liposomes loaded with the anticancer drug mitoxantrone (MTO). Plasma and tissue distribution profiles of LHRH receptor-targeted MTO-loaded liposomes (LHRH-MTO-LIPs) were quantified in healthy mice or a xenograft tumor nude mouse model of MCF-7 breast cancer and were compared with non-targeted liposomes and a free-drug solution. The LHRH-MTO-LIPs demonstrated a superior pharmacokinetic profile relative to free MTO. The first target site of accumulation is the kidney, followed by the liver, and then the tumor; maximal tumor accumulation occurs at 4...
全文获取路径: Dove 
影响因子:3.463 (2012)

  • hormone 激素
  • receptor 接受体
  • efficacy 效验
  • mitoxantrone 米托蒽醌
  • targeted 对准目标的
  • loaded 加负荷的
  • tumor 肿胀
  • peptide 
  • releasing 释放
  • breast 胸部