Rifapentine-linezolid-loaded PLGA microspheres for interventional therapy of cavitary pulmonary tuberculosis: preparation and in vitro characterization
作者: Jieyun HuangZhi ChenLi YingLi LiGuangyu Zhang
作者单位: 1Shanxi Medical University
2The 309th Hospital of Chinese PLA
3the Chinese Academy of Medical Sciences and Peking Union Medical College
刊名: Drug Design, Development and Therapy, 2017, Vol.2017 (default), pp.585-592
来源数据库: Dove Journal
DOI: 10.2147/DDDT.S127897
原始语种摘要: In this study, we aimed to design controlled-release microspheres for the treatment of cavitary pulmonary tuberculosis (TB) for solving the issues of poor drug delivery and short duration maintained at effective drug concentration during bronchoscopic interventional therapy. We fabricated rifapentine-linezolid-loaded poly(lactic acid-co-glycolic acid) (PLGA) microspheres (RLPMs)] using the oil-in-water emulsion solvent evaporation method and assessed their in vitro release as well as the bronchial mucosal retention characteristics. The microspheres are spherical in shape with circular concaves on the surface. The particle size of RLPMs was 27.38±1.28 μm. The drug loading of rifapentine and linezolid was 18.51±0.26 and 8.42±0.24%, respectively, while the encapsulation efficiencies were...
全文获取路径: Dove 
影响因子:3.486 (2012)

  • cavitary 腔的
  • pulmonary 肺的
  • loaded 加负荷的
  • tuberculosis 肺结核
  • mucosa 粘膜
  • rifapentine 利福喷丁
  • release 释放
  • bronchial 支气管的
  • retain 保持
  • therapy 治疗