Sustainable urban development is becoming the top concern of the nations in making and implementing the development policy systems. Sustainable urban development is a harmonious, effective development process with three pillars: economic development, social inclusion, and environmental management effectively. Vietnam is a rapidly urbanizing country. This process makes Vietnam’s cities face many major problems and challenges, especially sustainable economic development. Ho Chi Minh City is Vietnam’s largest city. It is the dynamic city with the fastest socio-economic development rate of Vietnam. The development of Ho Chi Minh City plays an important role in the overall development of the whole country. However, in the assessments of the authorities and experts, Ho Chi Minh City is growing... slowly and facing many big problems. Based on the analysis of the City’s potentials and advantages as well as the difficulties and challenges of the new development context, this paper recommends groups of solutions for sustainable economic development in Ho Chi Minh City in the next decades.