Cytomegalovirus protein m154 perturbs the adaptor protein-1 compartment mediating broad-spectrum immune evasion
作者: Ivana Strazic GeljicPaola Kucan BrlicGuillem AnguloIlija BrizicBerislav LisnicTina JenusVanda Juranic LisnicGian Pietro PietriPablo EngelNoa KaynanJelena ZeleznjakPeter SchuOfer MandelboimAstrid KrmpoticAna AnguloStipan JonjicTihana Lenac Rovis
作者单位: 11 Center for Proteomics, Faculty of Medicine University of Rijeka Rijeka Croatia
22 Immunology Unit, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences University of Barcelona Barcelona Spain
33 Department of Histology and Embryology, Faculty of Medicine University of Rijeka Rijeka Croatia
44 Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain
55 The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute, Hadassah Medical School The Hebrew University Jerusalem Israel
66 Zentrum für Biochemie und Molekulare Zellbiologie Institut für Zellbiochemie Georg-August-Universität Göttingen Goettingen Germany
刊名: eLife, 2020, Vol.9
来源数据库: eLife Sciences Publications, Ltd
DOI: 10.7554/eLife.50803
关键词: Immune evasionCytomegalovirusCMVPVRCD155M154 proteinAdaptor protein-1AP-1CD8+ T cells
原始语种摘要: Cytomegaloviruses (CMVs) are ubiquitous pathogens known to employ numerous immunoevasive strategies that significantly impair the ability of the immune system to eliminate the infected cells. Here, we report that the single mouse CMV (MCMV) protein, m154, downregulates multiple surface molecules involved in the activation and costimulation of the immune cells. We demonstrate that m154 uses its cytoplasmic tail motif, DD, to interfere with the adaptor protein-1 (AP-1) complex, implicated in intracellular protein sorting and packaging. As a consequence of the perturbed AP-1 sorting, m154 promotes lysosomal degradation of several proteins involved in T cell costimulation, thus impairing virus-specific CD8+ T cell response and virus control in vivo. Additionally, we show that HCMV infection...
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关键词翻译
关键词翻译
  • protein 蛋白质
  • immune 免疫的
  • evasion 规避
  • adaptor 注料口衬套
  • compartment 隔间
  • broad 宽的
  • sorting 分选酌
  • interfere 参预
  • antiviral 抗病毒的
  • spectrum 光谱