Activity-dependent death of transient Cajal-Retzius neurons is required for functional cortical wiring
作者: Martina RivaIoana GenescuChloé HabermacherDavid OrduzFanny LedonneFilippo M RijliGuillermina López-BenditoEva CoppolaSonia GarelMaria Cecilia AnguloAlessandra Pierani
作者单位: 11 Institut Imagine, Université de Paris Paris France
22 Institut Jacques Monod, CNRS UMR 7592, Université de Paris Paris France
33 Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, Université de Paris Paris France
44 Institut de Biologie de l’École Normale Supérieure (IBENS), Département de Biologie, École Normale Supérieure, CNRS, INSERM, Université PSL Paris France
55 INSERM U1128 Paris France
66 Friedrich Miescher Institute for Biomedical Research Basel Switzerland
77 Instituto de Neurosciencias de Alicante Universidad Miguel Hernandez Sant Joan d’Alacant Spain
刊名: eLife, 2019, Vol.8
来源数据库: eLife Sciences Publications, Ltd
DOI: 10.7554/eLife.50503
关键词: ApoptosisNeuronal activityCortical developmentExcitation/inhibition ratioCajal-Retzius neuronsTransient
原始语种摘要: Programmed cell death and early activity contribute to the emergence of functional cortical circuits. While most neuronal populations are scaled-down by death, some subpopulations are entirely eliminated, raising the question of the importance of such demise for cortical wiring. Here, we addressed this issue by focusing on Cajal-Retzius neurons (CRs), key players in cortical development that are eliminated in postnatal mice in part via Bax-dependent apoptosis. Using Bax-conditional mutants and CR hyperpolarization, we show that the survival of electrically active subsets of CRs triggers an increase in both dendrite complexity and spine density of upper layer pyramidal neurons, leading to an excitation/inhibition imbalance. The survival of these CRs is induced by hyperpolarization,...
全文获取路径: eLife科学出版社 

  • functional 功能的
  • required 必需
  • wiring 布线
  • cortical 皮层的
  • transient 瞬变现象
  • together 共同
  • proper 合适的
  • activity 活度
  • death 
  • development 开发