Defining murine monocyte differentiation into colonic and ileal macrophages
作者: Mor Gross-VeredSébastien TrzebanskiAnat ShemerBiana BernshteinCaterina CuratoGil StelzerTomer-Meir SalameEyal DavidSigalit Boura-HalfonLouise Chappell-MaorDena LeshkowitzSteffen Jung
作者单位: 11 Department of Immunology Weizmann Institute of Science Rehovot Israel
22 Bioinformatics Unit, Life Science Core Facilities Weizmann Institute of Science Rehovot Israel
刊名: eLife, 2020, Vol.9
来源数据库: eLife Sciences Publications, Ltd
DOI: 10.7554/eLife.49998
关键词: MonocytesMacrophagesIntestineColonIleum
原始语种摘要: Monocytes are circulating short-lived macrophage precursors that are recruited on demand from the blood to sites of inflammation and challenge. In steady state, classical monocytes give rise to vasculature-resident cells that patrol the luminal side of the endothelium. In addition, classical monocytes feed macrophage compartments of selected organs, including barrier tissues, such as the skin and intestine, as well as the heart. Monocyte differentiation under conditions of inflammation has been studied in considerable detail. In contrast, monocyte differentiation under non-inflammatory conditions remains less well understood. Here we took advantage of a combination of cell ablation and precursor engraftment to investigate the generation of gut macrophages from monocytes. Collectively, we...
全文获取路径: eLife科学出版社  (合作)

  • macrophages 巨噬细胞
  • monocyte 单核细胞
  • murine 鼠灰色
  • mature 成孰的
  • intestine 
  • remains 残渣
  • microbes 微生物
  • ulcerative 使...形成溃疡的
  • inflammation 炎症
  • cells 麻风细胞