A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life
作者: Weidong FengYinan LiPauline DaoJihad AburasPriota IslamBenayahu ElbazAnna KolarzykAndré EX BrownPaschalis Kratsios
作者单位: 11 Department of Neurobiology University of Chicago Chicago United States
22 Committee on Development, Regeneration and Stem Cell Biology University of Chicago Chicago United States
33 Committee on Neurobiology University of Chicago Chicago United States
44 MRC London Institute of Medical Sciences London United Kingdom
55 Institute of Clinical Sciences, Imperial College London London United Kingdom
66 Department of Neurology, Center for Peripheral Neuropathy University of Chicago Chicago United States
77 The Grossman Institute for Neuroscience, Quantitative Biology, and Human Behavior, University of Chicago Chicago United States
刊名: eLife, 2020, Vol.9
来源数据库: eLife Sciences Publications, Ltd
DOI: 10.7554/eLife.50065
关键词: Neuronal identityTranscription factorsHox proteinsTerminal selectorsUNC-3/Collier/Ebf
原始语种摘要: To become and remain functional, individual neuron types must select during development and maintain throughout life their distinct terminal identity features, such as expression of specific neurotransmitter receptors, ion channels and neuropeptides. Here, we report a molecular mechanism that enables cholinergic motor neurons (MNs) in the C. elegans ventral nerve cord to select and maintain their unique terminal identity. This mechanism relies on the dual function of the conserved terminal selector UNC-3 (Collier/Ebf). UNC-3 synergizes with LIN-39 (Scr/Dfd/Hox4-5) to directly co-activate multiple terminal identity traits specific to cholinergic MNs, but also antagonizes LIN-39’s ability to activate terminal features of alternative neuronal identities. Loss of unc-3 causes a switch in the...
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  • 特征 移动
  • identity 恒等性
  • terminal 顶端的
  • throughout 遍及
  • selector 选择器
  • cholinergic 胆碱能的
  • switch 开关
  • specific 
  • locomotion 移动
  • features 移动
  • safeguard 安全装置