Light-activatable cannabinoid prodrug for combined and target-specific photodynamic and cannabinoid therapy
作者: Xiaoxi LingShaojuan ZhangYang LiuMingfeng Bai
作者单位: 1University of Pittsburgh
2Vanderbilt University Institute of Imaging Sciences
3University of Pittsburgh Cancer Institute
刊名: Journal of Biomedical Optics, 2018, Vol.23 (10), pp.108001-108001
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.23.10.108001
关键词: Light-activatable prodrugPhotodynamic therapyCannabinoidCB2RCombination therapy
原始语种摘要: Cannabinoids are emerging as promising antitumor drugs. However, complete tumor eradication solely by cannabinoid therapy remains challenging. In this study, we developed a far-red light activatable cannabinoid prodrug, which allows for tumor-specific and combinatory cannabinoid and photodynamic therapy. This prodrug consists of a phthalocyanine photosensitizer (PS), reactive oxygen species (ROS)-sensitive linker, and cannabinoid. It targets the type-2 cannabinoid receptor (CB2R) overexpressed in various types of cancers. Upon the 690-nm light irradiation, the PS produces cytotoxic ROS, which simultaneously cleaves the ROS-sensitive linker and subsequently releases the cannabinoid drug. We found that this unique multifunctional prodrug design offered dramatically improved...
全文获取路径: SPIE  (合作)
影响因子:2.881 (2012)

  • prodrug 药物前体
  • cannabinoid 大麻的化学成分
  • photodynamic 在光中发荧光的
  • combined 组合
  • targeted 对准目标的
  • therapy 治疗
  • antitumor 抗癌的
  • dramatically 戏剧性地
  • therapeutic 治疗的
  • specific