In vivo isolation of the effects of melanin from underlying hemodynamics across skin types using spatial frequency domain spectroscopy
作者: Rolf B. SaagerAta SharifKristen M. KellyAnthony J. Durkin
作者单位: 1University of California, Irvine
刊名: Journal of Biomedical Optics, 2016, Vol.21 (5), pp.057001-057001
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.21.5.057001
关键词: oximetrytissue opticsstructured illuminationturbid mediaoptical propertiesdiffuse optical spectroscopyspatial frequency domainmelanin
原始语种摘要: Skin is a highly structured tissue, raising concerns as to whether skin pigmentation due to epidermal melanin may confound accurate measurements of underlying hemodynamics. Using both venous and arterial cuff occlusions as a means of inducing differential hemodynamic perturbations, we present analyses of spectra limited to the visible or near-infrared regime, in addition to a layered model approach. The influence of melanin, spanning Fitzpatrick skin types I to V, on underlying estimations of hemodynamics in skin as interpreted by these spectral regions are assessed. The layered model provides minimal cross-talk between melanin and hemodynamics and enables removal of problematic correlations between measured tissue oxygenation estimates and skin phototype.
全文获取路径: SPIE  (合作)
影响因子:2.881 (2012)

  • layered 成层的
  • hemodynamics 血力学
  • melanin 黑素
  • visible 看得见的
  • underlying 下伏的
  • spatial 空间的
  • regime 状况
  • spanning 生成
  • measured 量过的
  • inducing 施感的