Dual-mode endomicroscopy for detection of epithelial dysplasia in the mouth: a descriptive pilot study
作者: Nico BodenschatzCatherine F. PohSylvia LamPierre LaneMartial GuillaudCalum E. MacAulay
作者单位: 1British Columbia Cancer Research Centre
2The University of British Columbia
刊名: Journal of Biomedical Optics, 2017, Vol.22 (8), pp.086005-086005
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.22.8.086005
关键词: endomicroscopybiomedical opticsfluorescencelight scatteringin vivo pathology
原始语种摘要: Dual-mode endomicroscopy is a diagnostic tool for early cancer detection. It combines the high-resolution nuclear tissue contrast of fluorescence endomicroscopy with quantified depth-dependent epithelial backscattering as obtained by diffuse optical microscopy. In an in vivo pilot imaging study of 27 oral lesions from 21 patients, we demonstrate the complementary diagnostic value of both modalities and show correlations between grade of epithelial dysplasia and relative depth-dependent shifts in light backscattering. When combined, the two modalities provide diagnostic sensitivity to both moderate and severe epithelial dysplasia in vivo .
全文获取路径: SPIE  (合作)
影响因子:2.881 (2012)

  • epithelial 上皮的
  • dysplasia 发育异常
  • backscattering 后方散射
  • demonstrate 说明
  • study 学习
  • detection 探测
  • imaging 图像形成
  • optical 光学的
  • dependent 从属的
  • pilot 驾驶员