Breast tumor hemodynamic response during a breath-hold as a biomarker to predict chemotherapeutic efficacy: preclinical study
作者: Songhyun LeeJae Gwan Kim
作者单位: 1Gwangju Institute of Science and Technology
刊名: Journal of Biomedical Optics, 2018, Vol.23 (4), pp.048001-048001
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.23.4.048001
关键词: Inhalational oxygen gas modulationBreast cancerTumor vascular responseTherapeutic efficacy
原始语种摘要: Continuous wave diffuse optical tomographic/spectroscopic system does not provide absolute concentrations of chromophores in tissue and monitor only the changes of chromophore concentration. Therefore, it requires a perturbation of physiological signals, such as blood flow and oxygenation. In that sense, a few groups reported that monitoring a relative hemodynamic change during a breast tissue compression or a breath-hold to a patient can provide good contrast between tumor and nontumor. However, no longitudinal study reports the utilization of a breath-hold to predict tumor response during chemotherapy. A continuous wave near-infrared spectroscopy was employed to monitor hemodynamics in rat breast tumor during a hyperoxic to normoxic inhalational gas intervention to mimic a breath-hold...
全文获取路径: SPIE  (合作)
影响因子:2.881 (2012)

  • breath 气儿
  • efficacy 效验
  • chemotherapy 化学疗法
  • tumor 肿胀
  • biomarker 生物标志化合物
  • preclinical 临证前期的
  • response 响应
  • predict 预见
  • hemodynamic 血液动力的
  • oxyhemoglobin 氧合血红蛋白