Photoacoustic imaging using genetically encoded reporters: a review
作者: Joanna BrunkerJunjie YaoJan LauferSarah E. Bohndiek
作者单位: 1University of Cambridge
2Duke University
3Martin-Luther-Universität Halle-Wittenberg
刊名: Journal of Biomedical Optics, 2017, Vol.22 (7), pp.070901-070901
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.22.7.070901
关键词: genetic reportersin vivophotoacoustics
原始语种摘要: Genetically encoded contrast in photoacoustic imaging (PAI) is complementary to the intrinsic contrast provided by endogenous absorbing chromophores such as hemoglobin. The use of reporter genes expressing absorbing proteins opens the possibility of visualizing dynamic cellular and molecular processes. This is an enticing prospect but brings with it challenges and limitations associated with generating and detecting different types of reporters. The purpose of this review is to compare existing PAI reporters and signal detection strategies, thereby offering a practical guide, particularly for the nonbiologist, to choosing the most appropriate reporter for maximum sensitivity in the biological and technological system of interest.
全文获取路径: SPIE 
影响因子:2.881 (2012)

  • review 复审
  • technological 工芝的
  • prospect 预料
  • imaging 图像形成
  • purpose 目的
  • dynamic 动力学的
  • offering 报价
  • absorbing 吸收的
  • interest 兴趣
  • system