Development of a blood oxygenation phantom for photoacoustic tomography combined with online pO<sub>2</sub> detection and flow spectrometry
作者: Marcel GehrungSarah E. BohndiekJoanna Brunker
作者单位: 1Cancer Research UK Cambridge Institute
2University of Cambridge
刊名: Journal of Biomedical Optics, 2019, Vol.24 (12), pp.121908-121908
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.24.12.121908
关键词: Blood oxygenationFlowPhantomPhotoacoustic tomography
原始语种摘要: Photoacoustic tomography (PAT) is intrinsically sensitive to blood oxygen saturation (sO2) in vivo . However, making accurate sO2 measurements without knowledge of tissue- and instrumentation-related correction factors is extremely challenging. We have developed a low-cost flow phantom to facilitate validation of PAT systems. The phantom is composed of a flow circuit of tubing partially embedded within a tissue-mimicking material, with independent sensors providing online monitoring of the optical absorption spectrum and partial pressure of oxygen in the tube. We first test the flow phantom using two small molecule dyes that are frequently used for photoacoustic imaging: methylene blue and indocyanine green. We then demonstrate the potential of the phantom for...
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影响因子:2.881 (2012)

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关键词翻译
关键词翻译
  • phantom 受精台
  • sub 分段
  • tomography 断层x 线摄影
  • multispectral 多重谱的
  • photoacoustic 光声的
  • online 联机
  • oxygenation 加氧酌
  • accurate 精确的
  • blood 血液
  • demonstrate 说明