Self-guided reconstruction for time-domain fluorescence molecular lifetime tomography
作者: Chuangjian CaiWenjuan CaiJiaju ChengYuxuan YangJianwen Luo
作者单位: 1Tsinghua University
刊名: Journal of Biomedical Optics, 2016, Vol.21 (12), pp.126012-126012
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.21.12.126012
关键词: fluorescence molecular lifetime tomographytime domainL1 regularizationself-guided
原始语种摘要: Fluorescence probes have distinct yields and lifetimes when located in different environments, which makes the reconstruction of fluorescence molecular lifetime tomography (FMLT) challenging. To enhance the reconstruction performance of time-domain (TD) FMLT with heterogeneous targets, a self-guided L 1 regularization projected steepest descent (SGL1PSD) algorithm is proposed. Different from other algorithms performed in time domain, SGL1PSD introduces a time-resolved strategy into fluorescence yield reconstruction. The algorithm consists of four steps. Step 1 reconstructs the initial yield map with full time gate strategy; steps 2–4 reconstruct the inverse lifetime map, the yield map, and the inverse lifetime map again with time-resolved strategy, respectively. The reconstruction result...
全文获取路径: SPIE  (合作)
影响因子:2.881 (2012)

  • reconstruction 复原
  • regularization 正则化
  • tomography 断层x 线摄影
  • lifetime 寿命
  • steps 无扶手步梯
  • domain 领域
  • fluorescence 荧光
  • algorithm 算法
  • projected 计划中的
  • demonstrate 说明