Imaging of pharmacokinetic rates of indocyanine green in mouse liver with a hybrid fluorescence molecular tomography/x-ray computed tomography system
作者: Guanglei ZhangFei LiuBin ZhangYun HeJianwen LuoJing Bai
作者单位: 1Tsinghua University
刊名: Journal of Biomedical Optics, 2013, Vol.18 (4), pp.040505-040505
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.18.4.040505
关键词: fluorescence molecular tomographymultimodalitypharmacokinetic imaging
原始语种摘要: Pharmacokinetic rates have the potential to provide quantitative physiological and pathological information for biological studies and drug development. Fluorescence molecular tomography (FMT) is an attractive imaging tool for three-dimensionally resolving fluorophore distribution in small animals. In this letter, pharmacokinetic rates of indocyanine green (ICG) in mouse liver are imaged with a hybrid FMT and x-ray computed tomography (XCT) system. A recently developed FMT method using structural priors from an XCT system is adopted to improve the quality of FMT reconstruction. In the in vivo experiments, images of uptake and excretion rates of ICG in mouse liver are obtained, which can be used to quantitatively evaluate liver function. The accuracy of the results is validated by a...
全文获取路径: SPIE  (合作)
影响因子:2.881 (2012)

  • system 
  • rates 地方税
  • liver 
  • computed 计算的
  • mouse 小鼠
  • tomography 断层x 线摄影
  • fluorescence 荧光
  • development 开发
  • information 报告
  • recently 近来