Calibration-free absolute quantification of particle concentration by statistical analyses of photoacoustic signals in vivo
作者: Yong ZhouJunjie YaoKonstantin I. MaslovLihong V. Wang
作者单位: 1Washington University in St. Louis
刊名: Journal of Biomedical Optics, 2014, Vol.19 (3), pp.037001-037001
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.19.3.037001
关键词: photoacoustic imagingPoisson distributionparticle concentrationcalibration freered blood cell
原始语种摘要: Currently, laser fluence calibration is typically required for quantitative measurement of particle concentration in photoacoustic imaging. Here, we present a calibration-free method to quantify the absolute particle concentration by statistically analyzing photoacoustic signals. The proposed method is based on the fact that Brownian motion induces particle count fluctuation in the detection volume. If the count of particles in the detection volume is assumed to follow the Poisson distribution, its expected value can be calculated by the photoacoustic signal mean and variance. We first derived a theoretical model for photoacoustic signals. Then, we applied our method to quantitative measurement of different concentrations of various particles, including red blood cells. Finally, we...
全文获取路径: SPIE 
影响因子:2.881 (2012)

  • photoacoustic 光声的
  • particle 颗粒
  • concentration 浓度
  • absolute 绝对的
  • calibration 校准
  • measurement 测量
  • quantitative 量的
  • theoretical 理论的
  • statistically 统计地
  • imaging 图像形成