Enhancing in vivo renal ischemia assessment by high-dynamic-range fluorescence molecular imaging
作者: Yang GaoYuan ZhouFei LiuJianwen Luo
作者单位: 1Tsinghua University
2Beijing Jiaotong University
刊名: Journal of Biomedical Optics, 2018, Vol.23 (7), pp.076009-076009
来源数据库: SPIE-the International Society for Optical Engineering
DOI: 10.1117/1.JBO.23.7.076009
关键词: Fluorescence molecular imagingHigh-dynamic-rangeFluorophore distributionRenal ischemia assessment
原始语种摘要: Fluorescence imaging has been used to evaluate the physiological features of renal ischemia in animal model. However, the fluorophore distribution details of the ischemia model could not be fully represented due to the limited dynamic range of the charged-couple device. A high-dynamic-range (HDR) strategy was adopted in renal ischemia fluorescence imaging, both ex vivo and in vivo . The HDR strategy successfully combined ischemia relevant biological features that could only be captured with different exposure times, and then presented these features in the HDR results. The HDR results effectively highlighted the renal ischemic areas with relatively better perfusion and diminished the saturation that resulted from long exposure time. The relative fluorescence intensities of the ischemic...
全文获取路径: SPIE  (合作)
影响因子:2.881 (2012)

  • imaging 图像形成
  • dynamic 动力学的
  • renal 肾的
  • features 特征
  • ischemia 局部贫血
  • fluorescence 荧光
  • assessment 评价
  • molecular 分子的
  • range 射程
  • visualization 目测