Impaired thrombolytic status predicts adverse cardiac events in patients undergoing primary percutaneous coronary intervention
作者: Christos ChristopoulosMohamed FaragKeith SullivanDavid WellstedDiana A. Gorog
作者单位: 1Prof. Diana A. Gorog, Imperial College, London, UK, Tel.: +44 207 034 8934, E-mail:
刊名: Thromb Haemost, 2017, Vol.117 (3), pp.457-470
来源数据库: Schattauer GmbH
DOI: 10.1160/TH16-09-0712
关键词: Percutaneous coronary interventionthrombosisendogenous thrombolysismyocardial infarctioncoronary reperfusion
原始语种摘要: Antithrombotic medications reduce thrombosis but increase bleeding. Identification of ST-elevation myocardial infarction (STEMI) patients at risk of recurrent thrombosis could allow targeted treatment with potent antithrombotic medications, with less potent agents in others, to reduce bleeding. Conventional platelet function tests assess platelet reactivity only, yet there is increasing evidence that endogenous thrombolytic potential determines outcome following thrombus initiation. We investigated whether assessing both platelet reactivity and endogenous thrombolysis, could identify STEMI patients at high-risk of recurrent thrombotic events. Thrombotic status was assessed in STEMI patients, before and after primary percutaneous coronary intervention (PPCI), at discharge and at 30 days;...
影响因子:6.094 (2012)

  • thrombolytic 溶解血栓的
  • thrombolysis 血栓溶解
  • events 定时
  • intervention 
  • adverse 逆的
  • coronary 冠状的
  • endogenous 内成的
  • cardiac 贲门
  • percutaneous 经皮的
  • infarction 梗塞