Pathophysiological relevance of macrophage subsets in atherogenesis
作者: Luca LiberaleFranco DallegriFabrizio MontecuccoFederico Carbone
作者单位: 1Fabrizio Montecucco, MD, PhD, Department of Internal Medicine, University of Genoa School of Medicine, 6 viale Benedetto XV, 16132 Genoa, Italy, Tel.: +39 010 353 8694, Fax: +39 010 353 8686, E-mail:
刊名: Thromb Haemost, 2017, Vol.117 (1), pp.7-18
来源数据库: Schattauer GmbH
DOI: 10.1160/TH16-08-0593
关键词: Monocytemacrophagepolarisationatherosclerosis
原始语种摘要: Macrophages are highly heterogeneous and plastic cells. They were shown to play a critical role in all stages of atherogenesis, from the initiation to the necrotic core formation and plaque rupture. Lesional macrophages primarily derive from blood monocyte, but local macrophage proliferation as well as differentiation from smooth muscle cells have also been described. Within atherosclerotic plaques, macrophages rapidly respond to changes in the microenvironment, shifting between pro- (M1) or anti-inflammatory (M2) functional phenotypes. Furthermore, different stimuli have been associated with differentiation of newly discovered M2 subtypes: IL-4/IL-13 (M2a), immune-complex (M2b), IL-10/glucocorticoids (M2c), and adenosine receptor agonist (M2d). More recently, additional intraplaque...
全文获取路径: Schattauer 出版社 
影响因子:6.094 (2012)

  • atherogenesis 动脉粥样化形成
  • macrophage 巨噬细胞
  • plaque 
  • associated 相关的
  • oxidized 被氧化的
  • events 定时
  • cells 麻风细胞
  • phenotypic 表型的
  • respond 应答
  • monocyte 单核细胞