The fifth epidermal growth factor like region of thrombomodulin alleviates LPS-induced sepsis through interacting with GPR15
作者: Bin PanXiangmin WangShinsuke KojimaChie NishiokaAkihito YokoyamaGoichi HondaKailin XuTakayuki Ikezoe
作者单位: 1Kailin Xu, MD, Department of Hematology, The Affiliated Hospital of Xuzhou Medical University, #99 West Huaihai Road, Xuzhou 221002, China, Tel.: +86 516 8580 2382, Fax: +86 516 8560 1527, E-mail: lihmd@163.com
2Takayuki Ikezoe, MD, Department of Hematology, Fukushima Medical University, 1 Hikariga-oka, Fukushima City 960–1295, Japan, Tel.: +81 24 547 1190, Fax: +81 24 548 1821, E-mail: ikezoet@fmu.ac.jp
刊名: Thromb Haemost, 2017, Vol.117 (3), pp.570-579
来源数据库: Schattauer GmbH
DOI: 10.1160/TH16-10-0762
关键词: ThrombomodulinlipopolysaccharidesepsisG-protein coupled receptor 15macrophages
原始语种摘要: Thrombomodulin (TM) exerts cytoprotection via the fifth region of epidermal growth factor (EGF)-like domain of TM (TME5) by interacting with G-protein coupled receptor 15 (GPR15) expressed on cell surface of vascular endothelial cells. TM is also implied to mediate anti-inflammatory functions by unknown mechanism. By applying a lipopolysaccharide (LPS)-induced murine sepsis model, we assessed the role of TME5 in septic inflammation and coagulation. We found that TME5 treatment protected mice in association with ameliorating inflammation and coagulopathy in LPS-induced sepsis. Further study confirmed that TME5 bound GPR15 in vitro. Knock out of GPR15 abolished protective role of TME5 in sepsis model. GPR15 mediated anti-inflammatory function of TME5 through suppression of phosphorylation...
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影响因子:6.094 (2012)

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关键词翻译
关键词翻译
  • GPR General Purpose Register
  • LPS Laboratory Peripheral System
  • sepsis 败血症
  • induced 感应的
  • interacting 相克的
  • translocation 移位
  • inflammatory 激怒的
  • growth 生长
  • inflammation 炎症
  • immune 免疫的