Glucagon-like peptide 1-related peptides increase nitric oxide effects to reduce platelet activation
作者: Cristina BaraleSimona BuraccoFranco CavalotChiara FrascaroliAngelo GuerrasioIsabella Russo
作者单位: 1Dr. Isabella Russo, PhD, Internal Medicine and Metabolic Disease Unit, Department of Clinical and Biological Sciences of the Turin University, San Luigi Gonzaga Hospital, 10043 Orbassano (Turin), Italy, Tel.: + 39 011 9026622, Fax: + 39 011 9038639, E-mail: isabella.russo@unito.it
刊名: Thromb Haemost, 2017, Vol.117 (6), pp.1115-1128
来源数据库: Schattauer GmbH
DOI: 10.1160/TH16-07-0586
关键词: Plateletsglucagone-like peptide 1Liraglutidenitric oxidediabetes
原始语种摘要: Glucagon-like peptide 1 (GLP-1) is object of intensive investigation for not only its metabolic effects but also the protective vascular actions. Since platelets exert a primary role in the pathogenesis of atherosclerosis, inflammation and vascular complications, we investigated whether GLP-1 directly influences platelet reactivity. For this purpose, in platelets from 72 healthy volunteers we evaluated GLP-1 receptor (GLP-1R) expression and the effects of a 15-minute incubation with the native form GLP-1(7–36), the N-terminally truncated form GLP-1(9–36) and the GLP-1 analogue Liraglutide (100 nmol/l) on: i) aggregation induced by collagen or arachidonic acid (AA); ii) platelet function under shear stress; iii) cGMP and cAMP synthesis and cGMP-dependent protein kinase (PKG)-induced...
全文获取路径: Schattauer 出版社  (合作)
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影响因子:6.094 (2012)

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关键词翻译
关键词翻译
  • activation 活化
  • nitric 氮的
  • effects 海员自身物品
  • induced 感应的
  • peptide 
  • independently 独立地
  • exert 发挥
  • inhibitory 禁止的
  • increase 增加
  • reduced 减缩的