External validation of the VTE-BLEED score for predicting major bleeding in stable anticoagulated patients with venous thromboembolism
作者: Frederikus A. KlokStefano BarcoStavros V. Konstantinides
作者单位: 1Frederikus A. Klok, PhD, MD, FESC, Center for Thrombosis and Hemostasis, University Medical Centre Mainz, Langenbeckstrasse 1, Building 403; 55131 Mainz, Germany, Tel.: +49 6131 17 8382, Fax: +49 6131 17 3456, E-mail: f.a.klok@LUMC.nl
刊名: Thromb Haemost, 2017, Vol.117 (6), pp.1164-1170
来源数据库: Schattauer GmbH
DOI: 10.1160/TH16-10-0810
关键词: Anticoagulationwarfarinedoxabanclinical prediction rulebleedingpulmonary embolismdeep vein thrombosis
原始语种摘要: One of the main determinants of establishing the optimal treatment duration of patients with venous thromboembolism (VTE) is the risk of major bleeding during long-term anticoagulant therapy. The 6-variable VTE-BLEED score was recently developed to enable estimation of this bleeding risk. This study aimed at externally validating VTE-BLEED. This was a post-hoc study of the randomised, double-blind, double-dummy, Hokusai-VTE study that compared edoxaban versus warfarin for treatment of VTE. VTE-BLEED was calculated in all 8,240 study patients. The numbers of adjudicated major bleeding events during ‘stable anticoagulation’, i. e. occurring after day 30, in patients with low (total score <2 points) and high risk of bleeding (total score ≥2 points) were compared for the...
全文获取路径: Schattauer 出版社  (合作)
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影响因子:6.094 (2012)

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关键词翻译
关键词翻译
  • treatment 处理
  • major 知的
  • bleeding 模糊不清
  • score 得分
  • stable 稳定的
  • respectively 分别
  • double 双重的
  • warfarin 杀鼠灵
  • interval 区间
  • higher