Toxicity assessment of anatase and rutile titanium dioxide nanoparticles: The role of degradation in different pH conditions and light exposure
作者: Valeria De MatteisMariafrancesca CascioneVirgilio BrunettiChiara Cristina TomaRosaria Rinaldi
作者单位: 1Università del Salento, Dipartimento di Matematica e Fisica “Ennio De Giorgi”, Via Arnesano, 73100 Lecce, Italy
2Euromediterranean Center for Nanomaterial Modelling and Technology (ECMT) of Consiglio Nazionale delle Ricerche (CNR), Institute of Nanoscience, via Arnesano, 73100 Lecce, Italy
3Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia (CBN-IIT), via Barsanti, 73010, Arnesano, Lecce, Italy
刊名: Toxicology in Vitro, 2016, Vol.37 , pp.201-210
来源数据库: Elsevier Journal
DOI: 10.1016/j.tiv.2016.09.010
关键词: Titanium dioxideCytotoxicityIons releasepHSunlight exposure
英文摘要: Abstract(#br)Titanium dioxide nanoparticles (TiO 2 NPs), in the two crystalline forms, rutile and anatase, have been widely used in many industrial fields, especially in cosmetics. Therefore, a lot of details about their safety issues have been discussed by the scientific community. Many studies have led to a general agreement about TiO 2 NPs toxicity, in particular for anatase form, but no mechanism details have been proved yet. In this study, data confirm the different toxic potential of rutile and anatase TiO 2 NPs in two cell lines up to 5nM nanoparticles concentration. Moreover, we evaluated the role of titanium ions released by TiO 2 NPs in different conditions, at pH=4.5 (the typical lysosomal compartment pH) and at pH...
全文获取路径: Elsevier  (合作)
影响因子:2.65 (2012)