Glycyrrhetinic acid-modified poly(ethylene glycol)–b-poly(γ-benzyl l -glutamate) micelles for liver targeting therapy
作者: Wei HuangWei WangPing WangQin TianChuangnian ZhangChunhong WangZhi YuanMin LiuHaiying WanHua Tang
作者单位: 1Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin 300071, People’s Republic of China
2Tianjin Life Science Research Center, Tianjin Medical University, Tianjin 300070, People’s Republic of China
刊名: Acta Biomaterialia, 2010, Vol.6 (10), pp.3927-3935
来源数据库: Elsevier Journal
DOI: 10.1016/j.actbio.2010.04.021
关键词: Liver targetingGlycyrrhetinic acidBlock co-polymersMicellesDoxorubicin
英文摘要: Abstract(#br)Liver targeted micelles were successfully constructed via self-assembly of glycyrrhetinic acid (GA)-modified poly(ethylene glycol)–b-poly(γ-benzyl l -glutamate) (GA–PEG–PBLG) block co-polymers, which were fabricated via ring opening polymerization of γ-benzyl l -glutamate N-carboxyanhydride monomer initiated by GA-modified PEG. The in vivo biodistribution and the in vitro cellular uptake of these micelles were investigated. The results showed that the relative uptake of doxorubicin (DOX)-loaded micelles (DOX/GA–PEG–PBLG) in liver was much higher than in other tissues, and the resulting DOX concentration in liver was about 2.2-fold higher than that from the micelles without modification by GA. Moreover, the cellular uptake study demonstrated that the introduction of GA to the...
全文获取路径: Elsevier  (合作)
影响因子:5.093 (2012)