Mutagenic effects of gold nanoparticles induce aberrant phenotypes in Drosophila melanogaster
作者: Giuseppe VecchioAntonio GaleoneVirgilio BrunettiGabriele MaioranoLoris RizzelloStefania SabellaRoberto CingolaniPier P. Pompa
作者单位: 1Italian Institute of Technology, Center for Bio-Molecular Nanotechnologies @UniLe, Arnesano (Lecce), Italy
2Italian Institute of Technology, Central Research Laboratories, Genova, Italy
刊名: Nanomedicine: Nanotechnology, Biology, and Medicine, 2011, Vol.8 (1), pp.1-7
来源数据库: Elsevier Journal
DOI: 10.1016/j.nano.2011.11.001
关键词: NanotoxicologyGold nanoparticlesDrosophila melanogasterGenotoxicity
原始语种摘要: Abstract(#br)The peculiar physical/chemical characteristics of engineered nanomaterials have led to a rapid increase of nanotechnology-based applications in many fields. However, before exploiting their huge and wide potential, it is necessary to assess their effects upon interaction with living systems. In this context, the screening of nanomaterials to evaluate their possible toxicity and understand the underlying mechanisms currently represents a crucial opportunity to prevent severe harmful effects in the next future. In this work we show the in vivo toxicity of gold nanoparticles (Au NPs) in Drosophila melanogaster , highlighting significant genotoxic effects and, thus, revealing an unsettling aspect of the long-term outcome of the exposure to this nanomaterial. After the treatment...
全文获取路径: Elsevier  (合作)