Methylenetetrahydrofolate reductase (MTHFR) variants and bladder cancer: A population-based case-control study
作者: Margaret R. KaragasSunyeong ParkHeather H. NelsonAngeline S. AndrewLeila MottAlan SchnedKarl T. Kelsey
作者单位: 1Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH, USA
2Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA, USA
3Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
4Department of Pathology, Dartmouth Medical School, Lebanon, NH, USA
刊名: International Journal of Hygiene and Environmental Health, 2005, Vol.208 (5), pp.321-327
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijheh.2005.04.005
关键词: Bladder cancerCase-control studyGene–environment interactionArsenicSmokingMethylenetetrahydrofolate reductase polymorphisms
原始语种摘要: Abstract(#br)Functional variants in the methylenetetrahydrofolate reductase ( MTHFR ) gene, including the 677C>T and 1298A>C polymorphisms, have been associated with a moderately reduced risk of several cancers, including colorectal cancers. While recent studies have investigated the role of these polymorphisms on bladder cancer susceptibility, results have been mixed. To clarify the role of MTHFR polymorphisms on bladder cancer risk, we genotyped MTHFR 677C>T and MTHFR 1298A>C in a population-based study of bladder cancer of 352 patients and 551 controls from New Hampshire, USA. The allelic frequency was 35.6% for MTHFR 677C>T and 40.4% for MTHFR 1298A>C among controls. We found no evidence of a main gene effect for either polymorphism (adjusted OR for MTHFR 677C>T variants versus the...
全文获取路径: Elsevier  (合作)