Optimizing combination rifampin therapy for staphylococcal osteoarticular infections
作者: Guillaume CoiffierJean-David AlbertCédric ArvieuxPascal Guggenbuhl
作者单位: 1Service de rhumatologie, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, 35203 Rennes cedex 2, France
2Clinique des maladies infectieuses, CHU de Rennes–Pontchaillou, rue Henri-Le-Guilloux, 35043 Rennes cedex, France
3Centre de référence en infections ostéo-articulaires complexes du Grand-Ouest (CRIOGO), CHU de Rennes, Rennes, France
刊名: Joint Bone Spine, 2013, Vol.80 (1), pp.11-17
来源数据库: Elsevier Journal
DOI: 10.1016/j.jbspin.2012.09.008
关键词: Rifampicin staphylococcusOsteoarticular infectionsAntibioticsSeptic arthritis
原始语种摘要: Abstract(#br)Staphylococcus spp. causes more than half of all osteoarticular infections of native structures or implanted material. The ability of Staphylococcus spp. to persist within infected bone tissue and to produce a bacterial biofilm, most notably in infections of implanted material, can lead to treatment failures and microbiological relapses. Rifampin is a cornerstone of the treatment of staphylococcal osteoarticular infections, particularly those of implanted material. Rifampin is a bactericidal antibiotic that diffuses very well within bone tissue and bacterial biofilms. The mechanism of action is inhibition of bacterial DNA transcription to mRNA independently from bacterial division, which results in activity against even dormant Staphylococcus spp. organisms. However, the high...
全文获取路径: Elsevier  (合作)
影响因子:2.748 (2012)