Tissue assembly and organization: Developmental mechanisms in microfabricated tissues
作者: Nicolas C. RivronJeroen RouwkemaRoman TruckenmüllerMarcel KarperienJan De BoerClemens A. Van Blitterswijk
作者单位: 1Department of Tissue Regeneration, Institute for BioMedical Technology, University of Twente, Zuidhorst, P.O. Box 217, Enschede 7500 AE, The Netherlands
刊名: Biomaterials, 2009, Vol.30 (28), pp.4851-4858
来源数据库: Elsevier Journal
DOI: 10.1016/j.biomaterials.2009.06.037
关键词: Self-organizationMorphogenesisMicroscale tissue engineering
英文摘要: Abstract(#br)In vitro -generated tissues hold significant promise in modern biology since they can potentially mimic physiological and pathological tissues. However, these are currently structurally and functionally of limited complexity and necessitate self-organization and recapitulation of tissue development mechanisms in vitro . Tools derived from nano- and microfabrications along with bottom-up strategies are emerging to allow the fabrication of primitive tissues structures that can remodel overtime. Subsequently, clues are accumulating to show that, beyond genetic material, both intrinsic tissue architectures and microenvironmental cues can lead to morphogenesis related mechanisms in vitro . The question arises, however, as how we may design and assemble structures prone to adequate...
全文获取路径: Elsevier  (合作)
影响因子:7.604 (2012)