Cytoprotective effect of vitamin C against gentamicin-induced acute kidney injury in rats
作者: Nenad StojiljkovicMilan StoiljkovicPavle RandjelovicSlavimir VeljkovicDragan Mihailovic
作者单位: 1Department of Physiology, University of Nis School of Medicine, Nis, Serbia
2Department of Pharmacology and Toxicology, University of Nis School of Medicine, Bulevar Dr Zorana Djindjica 81, 18000 Nis, Serbia
3Department of Pathology, University of Nis School of Medicine, Nis, Serbia
刊名: Experimental and Toxicologic Pathology, 2010, Vol.64 (1), pp.69-74
来源数据库: Elsevier Journal
DOI: 10.1016/j.etp.2010.06.008
关键词: GentamicinNephrotoxicityVitamin CMorphometryRats
原始语种摘要: Abstract(#br)Since gentamicin-induced nephrotoxicity has very important clinical consequences, different potentially therapeutic approaches to prevent or attenuate it have been proposed.(#br)Accordingly, this study aimed at determining the possible protective effects of vitamin C against gentamicin-associated acute kidney injury.(#br)Experiments were done on 40 adult Wistar rats divided into four groups of 10 animals each. G-group received gentamicin (100mg/kg) while GVC-group received the same dose of gentamicin and vitamin C (200mg/kg) by intraperitoneal injections on a daily basis. Animals in VC-group, serving as a positive control, received only vitamin C (200mg/kg), and those in C-group, serving as a negative control, received...
全文获取路径: Elsevier  (合作)
影响因子:2.622 (2012)