A possible association between the genetic predisposition for dizygotic twinning and schizophrenia
作者: Ulla KläningCarsten Bøcker PedersenPreben Bo MortensenKirsten Ohm KyvikAxel Skytthe
作者单位: 1Centre of Clinical Psychiatric Research, Mood Disorder Research Unit, Psychiatric Hospital in Aarhus, Skovagervej 2, 8240 Risskov, Denmark
2Department of Psychiatric Demography, Institute for Basic Psychiatric Research, Aarhus University Hospital and the National Centre for Register-based Research, Aarhus University, Denmark
3The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Denmark
4Danish Centre for Demographic Research and the Danish Twin Registry, University of Southern Denmark, Denmark
刊名: Schizophrenia Research, 2002, Vol.58 (1), pp.31-35
来源数据库: Elsevier Journal
DOI: 10.1016/S0920-9964(01)00343-7
关键词: Dizygotic twinsSchizophreniaGenes
原始语种摘要: Abstract(#br)Background : A previous study demonstrated a 40% higher rate of schizophrenia in dizygotic twins than in the general population. The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated. Method : Through record linkage between The Danish Twin Register, The Danish Psychiatric Central Register, and The Danish Civil Registration System, the rate of schizophrenia in singleton siblings of dizygotic and monozygotic twins was compared with the rate in siblings of singletons. Results : The rate of first admission to hospital for schizophrenia in siblings of dizygotic twins was 35% greater than the rate in siblings of singletons. The result was statistically significant (...
全文获取路径: Elsevier  (合作)
影响因子:4.59 (2012)