Human papillomavirus type 16 E6, E7, and L1 variants in cervical cancer in Indonesia, Suriname, and The Netherlands
作者: Marjon A de BoerLex A.W PetersMohammed Farid AzizBudiningsih SiregarSantoso CornainM.Albert VredeEkaterina S JordanovaSandra Kolkman-UljeeGert Jan Fleuren
作者单位: 1Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
2Department of Gynecology, Leiden University Medical Center, Leiden, The Netherlands
3Division of Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
4Department of Anatomic Pathology, Faculty of Medicine, Jakarta, Indonesia
5Department of Pathology, Academic Hospital Paramaribo, Suriname
刊名: Gynecologic Oncology, 2004, Vol.94 (2), pp.488-494
来源数据库: Elsevier Journal
DOI: 10.1016/j.ygyno.2004.05.037
关键词: Human papillomavirus type 16VariantCervical cancer
原始语种摘要: Abstract(#br)Objective . Human papillomavirus type 16 (HPV 16) has several intratypic variants, and some are associated with enhanced oncogenic potential. For risk determination as well as for future vaccine development, knowledge about variants is important. Regarding the geographical distribution of HPV variants and the lack of data from Indonesia and Suriname, we studied the prevalence of HPV 16 variants in cervical cancer in these high incidence countries. Data were compared with The Netherlands, a low-risk country.(#br)Methods . DNA samples from 74 formalin-fixed paraffin-embedded HPV 16-positive cervical carcinomas from Indonesia (Java, N = 22), Suriname ( N = 25), and The Netherlands ( N = 27) were amplified using primers specific for the E6, E7, and part of the L1 regions....
全文获取路径: Elsevier  (合作)
影响因子:3.929 (2012)