Gastric antisecretory and antiulcer activity of oxytocin in rats and guinea pigs
作者: Mohammed AsadDeepak Gopal ShewadeKailasam KoumaravelouBenny K. AbrahamSadashivam VasuSubramaniam Ramaswamy
作者单位: 1Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry-605 006, India
刊名: Life Sciences, 2001, Vol.70 (1), pp.17-24
来源数据库: Elsevier Journal
DOI: 10.1016/S0024-3205(01)01376-5
关键词: OxytocinAtosibanGastric ulcerAcid secretionIndomethacinHistamineCysteamine
原始语种摘要: Abstract(#br)The effect of oxytocin (1 mg/kg s.c) on gastric acid secretion and on different experimentally induced gastric and duodenal ulcers was studied. The acute gastric ulcer models used were pylorus ligation, indomethacin, ethanol and histamine induced acute gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by cysteamine hydrochloride. Oxytocin showed significant antisecretory and antiulcer activity in pylorus ligated rats. Similarly oxytocin reduced the ulcer index in histamine induced gastric ulcers in guinea pigs and cysteamine induced duodenal ulcers in rats. The antiulcer and antisecretory effect was comparable to that of ranitidine (50mg/kg, i.p) though less in intensity. However, it did not show any gastric cytoprotective effect in...
全文获取路径: Elsevier  (合作)
影响因子:2.555 (2012)