Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice
作者: Laura GioiosaXuqi ChenRebecca WatkinsNicole KlanferCamron D. BryantChristopher J. EvansArthur P. Arnold
作者单位: 1Department of Physiological Science, and Laboratory of Neuroendocrinology of the Brain Research Institute, University of California, Los Angeles, CA 90095, USA
2Shirley and Stefan Hatos Center for Neuropharmacology, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA
刊名: Hormones and Behavior, 2007, Vol.53 (1), pp.124-130
来源数据库: Elsevier Journal
DOI: 10.1016/j.yhbeh.2007.09.003
关键词: X chromosomeY chromosomePainSex differenceHotplateSex chromosomes
原始语种摘要: Abstract(#br)We tested the role of sex chromosome complement and gonadal hormones in sex differences in several different paradigms measuring nociception and opioid analgesia using “four core genotypes” C57BL/6J mice. The genotypes include XX and XY gonadal males, and XX and XY gonadal females. Adult mice were gonadectomized and tested 3–4 weeks later, so that differences between sexes (mice with testes vs. ovaries) were attributable mainly to organizational effects of gonadal hormones, whereas differences between XX and XY mice were attributable to their complement of sex chromosomes. In Experiment 1 (hotplate test of acute morphine analgesia), XX mice of both gonadal sexes had significantly shorter hotplate baseline latencies prior to morphine than XY mice. In Experiment 2 (test of...
全文获取路径: Elsevier  (合作)
影响因子:3.735 (2012)