Fate of HERS during tooth root development
| 作者： | Xiaofeng Huang, Pablo Bringas, Harold C. Slavkin, Yang Chai |
| 作者单位： |
1Center for Craniofacial Molecular Biology (CCMB), School of Dentistry, University of Southern California, 2250 Alcazar St. CSA 103, Los Angeles, CA 90033, USA 2Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China |
| 刊名： | Developmental Biology, 2009, Vol.334 (1), pp.22-30 |
| 来源数据库： | Elsevier Journal |
| DOI： | 10.1016/j.ydbio.2009.06.034 |
| 关键词： | HERS; Tooth root; Tooth root development; Cre recombinase; LacZ; ROSA26 conditional reporter ( R26R ); K14 promoter; Wnt1 promoter; Cementum; |
| 原始语种摘要： | Abstract(#br)Tooth root development begins after the completion of crown formation in mammals. Previous studies have shown that Hertwig's epithelial root sheath (HERS) plays an important role in root development, but the fate of HERS has remained unknown. In order to investigate the morphological fate and analyze the dynamic movement of HERS cells in vivo, we generated K14-Cre;R26R mice. HERS cells are detectable on the surface of the root throughout root formation and do not disappear. Most of the HERS cells are attached to the surface of the cementum, and others separate to become the epithelial rest of Malassez. HERS cells secrete extracellular matrix components onto the surface of the dentin before dental follicle cells penetrate the HERS network to contact dentin. HERS cells also... |
