Targeting of cre to the Foxg1 ( BF-1 ) Locus Mediates loxP Recombination in the Telencephalon and Other Developing Head Structures
作者: Jean M HébertSusan K McConnell
作者单位: 1Department of Biological Sciences, Stanford University, Stanford, California, 94305-5020
刊名: Developmental Biology, 2000, Vol.222 (2), pp.296-306
来源数据库: Elsevier Journal
DOI: 10.1006/dbio.2000.9732
关键词: BF-1Foxg1Cre/loxPFoxg1-Cretelencephaloncerebral cortexhippocampusstriatumR26RZ/AP
原始语种摘要: Abstract(#br)The use of genetics to study the development of the telencephalon and derivatives such as the cerebral cortex has been limited. The telencephalon begins to form midway through gestation, and targeted mutations in genes suspected of playing roles in its development often lead to early phenotypes that preclude analysis of their role at later stages. This problem can be circumvented using a Cre/ loxP recombination system. A mouse line was produced in which cre was targeted to the Foxg1 ( BF-1 ) locus, a gene expressed specifically in the telencephalon and discrete head structures. Crosses between Foxg1–Cre mice and three separate loxP reporter mice generated embryos with recombination patterns matching that expected from the normal pattern of Foxg1 expression. Recombination...
全文获取路径: Elsevier  (合作)
影响因子:3.868 (2012)