Phenotypic screening of hepatocyte nuclear factor (HNF) 4-γ receptor knockout mice
作者: Anna Karin GerdinVikas V. SurveMarie JönssonMikael BjursellMaria BjörkmanAnne EdenroMeint SchuelkeAlaa SaadSivert BjurströmElisabeth Jensen LundgrenMichael SnaithRonny Fransson-SteenJan TörnellAnna-Lena BergMohammad Bohlooly-Y
作者单位: 1AstraZeneca Transgenic and Comparative Genomics, AstraZeneca R&D, Mölndal, Sweden
2Safety Assessment Sweden, AstraZeneca R&D, Södertälje, Sweden
3Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at Göteborg University, Sweden
刊名: Biochemical and Biophysical Research Communications, 2006, Vol.349 (2), pp.825-832
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2006.08.103
关键词: Phenotype screeningHNF4-γEnergy expenditureBehaviour
英文摘要: Abstract(#br)Using the mouse as a model organism in pharmaceutical research presents unique advantages as its physiology in many ways resembles the human physiology, it also has a relatively short generation time, low breeding and maintenance costs, and is available in a wide variety of inbred strains. The ability to genetically modify mouse embryonic stem cells to generate mouse models that better mimic human disease is another advantage. In the present study, a comprehensive phenotypic screening protocol is applied to elucidate the phenotype of a novel mouse knockout model of hepatocyte nuclear factor (HNF) 4-γ. HNF4-γ is expressed in the kidneys, gut, pancreas, and testis. The first level of the screen is aimed at general health, morphologic appearance, normal cage behaviour, and gross...
全文获取路径: Elsevier  (合作)