Low-dose endotoxemia and human neuropsychological functions
作者: Karen Suárez KrabbeAbraham ReichenbergRaz YirmiyaAnnelise SmedBente Klarlund PedersenHelle Bruunsgaard
作者单位: 1Centre of Inflammation and Metabolism, Department of Infectious Diseases, University of Copenhagen, Denmark
2Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health, University of Copenhagen, Denmark
3Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
4Department of Psychology, The Hebrew University of Jerusalem, Israel
5Neurological Clinic, Rigshospitalet, Denmark
刊名: Brain Behavior and Immunity, 2005, Vol.19 (5), pp.453-460
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbi.2005.04.010
关键词: EndotoxinInflammationCognitive functionCytokines
英文摘要: Abstract(#br)Epidemiological data demonstrate an association between systemic low-grade inflammation defined as 2- to 3-fold increases in circulating inflammatory mediators and age-related decline in cognitive function. However, it is not known whether small elevations of circulating cytokine levels cause direct effects on human neuropsychological functions. We investigated changes in emotional, cognitive, and inflammatory parameters in an experimental in vivo model of low-grade inflammation. In a double-blind crossover study, 12 healthy young males completed neuropsychological tests before as well as 1.5, 6, and 24h after an intravenous injection of Escherichia coli endotoxin (0.2ng/kg) or saline in two experimental sessions. Endotoxin administration...
全文获取路径: Elsevier  (合作)
影响因子:5.612 (2012)