Purely aqueous PLGA nanoparticulate formulations of curcumin exhibit enhanced anticancer activity with dependence on the combination of the carrier
作者: K. Lekha NairArun Kumar T. ThulasidasanG. DeepaRuby John AntoG.S. Vinod Kumar
作者单位: 1Chemical Biology, Molecular Medicine Division, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram 695 014, Kerala, India
2Cancer Research, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thiruvananthapuram 695 014, Kerala, India
刊名: International Journal of Pharmaceutics, 2012, Vol.425 (1-2), pp.44-52
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijpharm.2012.01.003
关键词: CurcuminPLGA combinationsAqueous nanocurcuminHeLaAntitumor activity
原始语种摘要: Abstract(#br)Curcumin, a yellow pigment present in turmeric, possess potential anti-proliferative and anti-inflammatory activities but poor aqueous solubility limits its applications. In this study we report a novel comparative study of the formulation and characterization of curcumin nanoparticles (nanocurcumin) using two poly (lactide-co-glycolide) (PLGA) combinations, 50:50 and 75:25 having different lactide to glycolide ratios. Nanocurcumin 50:50 showed smaller size with higher encapsulation efficiency. Thermal evaluation suggested the presence of curcumin in molecular dispersion form which supported its sustained release up to a week where nanocurcumin 50:50 showed faster release. Cellular uptake studies in human epithelial cervical cancer cells (HeLa) exhibited enhanced...
全文获取路径: Elsevier  (合作)
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影响因子:3.458 (2012)

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