Cyclooxygenase-2 contributes to VX-induced cell death in cultured cortical neurons
作者: Catherine C. TennM. Tracy WeissClaire BeaupAndre PeinnequinYushan WangFrederic Dorandeu
作者单位: 1DRDC Suffield, P.O. Box 4000, Station Main, Medicine Hat, Alberta, Canada T1A 8K6
2Institut de Recherche Biomédicale des Armées – Centre de Recherches du Service de Santé des Armées (CRSSA), Département de Toxicologie et risques chimiques, BP 87, La Tronche Cedex, France
3Ecole du Val-de-Grâce, 1 place Alphonse Laveran, 75230 Paris, France
刊名: Toxicology Letters, 2012, Vol.210 (1), pp.71-77
来源数据库: Elsevier Journal
DOI: 10.1016/j.toxlet.2012.01.016
关键词: Nerve agentCOX-2Cell deathProstaglandinsNeurotoxicityNeurons
原始语种摘要: Abstract(#br)The link between cell death and increased cyclooxygenases-2 (COX-2) activity has not been clearly established. In this study, we examined whether COX-2 activation contributed to the mechanism of neurotoxicity produced by an organophosphorous nerve agent in cultured rat cortical neurons. Exposure of neuronal cells to the nerve agent, VX resulted in an increase in COX enzyme activity in the culture media. A concentration dependent increase in the activity levels of COX-2 enzyme was observed while there was little to no effect on COX-1. In addition, COX-2 mRNA and protein levels increased several hours post-VX exposure. Pre-treatment of the cortical cells with the COX-2 selective inhibitor, NS 398 resulted in a decrease in both the enzyme activity and prostaglandin (PGE 2 and...
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:3.145 (2012)

×