Highly sensitive room-temperature method of non-invasive in vivo detection of magnetic nanoparticles
作者: Maxim P. NikitinPetr M. VetoshkoNikolai A. BrusentsovPetr I. Nikitin
作者单位: 1Department of Molecular & Biological Physics, Moscow Institute of Physics & Technology, Dolgoprudny, 9 Institutskii per., Moscow Region 117303, Russia
2Institute of Radioengineering and Electronics, Russian Academy of Sciences, 11 Mokhovaya Street, Moscow 103907, Russia
3N.N. Blokhin SE Russian Cancer Research Center RAMS, Moscow 115478, Russia
4Natural Science Center, A.M. Prokhorov General Physics Institute, Russian Academy of Sciences, 38 Vavilov Street, Moscow 119991, Russia
刊名: Journal of Magnetism and Magnetic Materials, 2009, Vol.321 (10), pp.1658-1661
来源数据库: Elsevier Journal
DOI: 10.1016/j.jmmm.2009.02.108
关键词: Magnetic and superparamagnetic nanoparticlesNon-invasive in vivo detectionNon-linear magnetic materialsDetection at combinatorial frequenciesMagnetic drug deliveryHyperthermiaMagnetic immunoassay
原始语种摘要: Abstract(#br)Methods of non-invasive in vivo quantification of magnetic nanoparticles (MP) have been proposed and realized. The methods are based on non-linear MP magnetization at two frequencies and measuring the response at combinatorial frequencies. The first method is developed for real-time study of MP dynamics and their clearance from the blood system of animals. High sensitivity of 3ng of Fe 3 O 4 in 0.1ml was achieved for MP detection in mice tail veins. The second technique is proposed for MP detection inside animal tissues by an external probe. The proposed methods could essentially widen capabilities of biomedical research which involves magnetic nanoparticles.
全文获取路径: Elsevier  (合作)
影响因子:1.826 (2012)