Gestational choriocarcinoma of the ovary diagnosed by analysis of tumour DNA
作者: P.C. LoriganA.J. GriersonJ.R. GoepelR.E. ColemanM.H. Goyns
作者单位: 1YCRC Department of Clinical Oncology, Weston Park Hospital, Whittam Road, Sheffield, S10 2SJ, UK
2Institute for Cancer Studies, Sheffield University Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
3Department of Pathology, Sheffield University Medical School, Beech Hill Road, Sheffield, S10 2RX, UK
刊名: Cancer Letters, 1996, Vol.104 (1), pp.27-30
来源数据库: Elsevier Journal
DOI: 10.1016/0304-3835(96)04219-X
关键词: ChoriocarcinomaGestationalAllelic heterozygosity
原始语种摘要: Abstract(#br)Gestational choriocarcinoma of the ovary is a rare form of malignancy which can be difficult to distinguish from primary ovarian choriocarcinoma. The ability to make such a diagnosis could, however, have important implications for therapy. We report here a case of choriocarcinoma whose origins were difficult to determine and which behaved clinically more like a primary rather than a gestational choriocarcinoma. We have analysed DNA from this tumour by using polymerase chain reaction (PCR) amplification of a range of polymorphic alleles and have demonstrated that the tumour was in fact gestational. Furthermore, the lack of chromosome Y sequences and the presence of heterozygosity of the spouse's alleles, indicated that this tumour arose as a result of dispermic fertilisation...
全文获取路径: Elsevier  (合作)
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影响因子:4.258 (2012)

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