CYP1A1 alleles in female genital cancers in the Polish population
作者: Agnieszka Seremak-MrozikiewiczKrzysztof DrewsAndrzej SemczukJerzy A. JakowickiPrzemyslaw M. Mrozikiewicz
作者单位: 1Department of Perinatology and Gynaecology, Division of Perinatology, Karol Marcinkowski University of Medical Sciences, Polna Street 33, Poznań 60-535, Poland
2Institute of Clinical Pharmacology, Humboldt University of Berlin, Charité, Berlin, Germany
3Research Institute of Medicinal Plants, Poznań, Poland
4Department of Gynaecological Surgery, Lublin School of Medicine, Lublin, Poland
刊名: European Journal of Obstetrics and Gynecology, 2004, Vol.118 (2), pp.246-250
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejogrb.2004.06.036
关键词: Ovarian cancerEndometrial cancerPolymorphismCytochrome P4501A1CYP1A1
原始语种摘要: Abstract(#br)Objective:(#br)Cytochrome P4501A1 (CYP1A1) plays an important role in the bioactivation processes that transform aromatic hydrocarbons into ultimate carcinogens. Genetically determined differences in activity of this enzyme could modulate individual susceptibility to develop cancers. The role of CYP1A1 in metabolic pathway of estrogens suggests an influence on carcinogenic events in genital tissues. The aim of our study was to elucidate the possible role of CYP1A1 alleles in the pathogenesis of endometrial and ovarian cancers.(#br)Study design:(#br)We have compared CYP1A1 genotype frequency between genital (endometrial and ovarian) cancer groups and 212 healthy women. Cancer patients were stratified using FIGO classification and diagnoses were confirmed histopathologically....
全文获取路径: Elsevier  (合作)