Multiple point action mechanism of valproic acid-teratogenicity alleviated by folic acid, vitamin C, And N-acetylcysteine in chicken embryo model
作者: Chiu-Lan HsiehHui-Er WangWan-Jane TsaiChiung-Chi PengRobert Y. Peng
作者单位: 1Graduate Institute of Biotechnology, Changhua University of Education, Jin-De Campus, 1 Jin-De Rd., Changhua 50007, Taiwan
2Department of Food Science and Applied Technology, Hungkuang University, 34 Chung-Chie Rd., Shalu County, Taichung Hsien 43302, Taiwan
3Graduate Institute of Rehabilitation Science, College of Health Care, China Medical University, 91 Hsueh-Shih Rd., Taichung 40202, Taiwan
4Department of Physical Therapy, College of Health Care, China Medical University, 91 Hsueh-Shih Rd., Taichung 40202, Taiwan
5Graduate Institute of Clinical Medicine, Taipei Medical University, 250 Wu-Xin St., Taipei 110, Taiwan
6Research Institute of Biotechnology, Hungkuang University, 34 Chung-Chie Rd., Shalu County, Taichung Hsien 43302, Taiwan
刊名: Toxicology, 2012, Vol.291 (1-3), pp.32-42
来源数据库: Elsevier Journal
DOI: 10.1016/j.tox.2011.10.015
关键词: Valproic acidFolic acidAscorbic acidN-acetylcysteineHistone deacetylase
原始语种摘要: Abstract(#br)The teratogenicity of antiepilepsy drug valproic acid (VPA) mostly is found in genetic and somatic levels, causing teratogenesis involving neurotubular defects (NTDs), anencephaly, lumbosacral meningomyelocele, and leg dysfunction due to spina bifida aperta. A diversity of nutraceutics have been tried to alleviate the risk of VPA-teratogenicity. The effect was varying. In order to promote the preventive prescription, to find out its action mechanism can be rather crucial. We used chicken embryo model to try the effect of folic acid (FA), ascorbic acid (AA), and N-acetyl cysteine (NAC). VPA at 30mM showed the higher malformation rate (66.7%) with the least mortality (22.2%). Pathological findings indicated that the cervical muscle was more susceptible to VPA...
全文获取路径: Elsevier  (合作)
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影响因子:4.017 (2012)

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