Early Left Ventricular Abnormalities in Children with Heterozygous Familial Hypercholesterolemia
作者: Giovanni Di SalvoAngelo Fabio D’AielloBiagio CastaldiBahaa FadelGiuseppe LimongelliAntonello D’AndreaValeria PergolaGiuseppe PacileoEmanuele Miraglia Del GiudiceLaura PerroneRaffaele CalabròMaria Giovanna Russo
作者单位: 1Second University of Naples, Monaldi Hospital, Naples, Italy
2King Faisal Specialist Hospital and Research Center, Heart Institute, Riyadh, Saudi Arabia
刊名: Journal of the American Society of Echocardiography, 2012, Vol.25 (10), pp.1075-1082
来源数据库: Elsevier Journal
DOI: 10.1016/j.echo.2012.07.002
关键词: Familial hypercholesterolemiaVentricular functionChildrenSpeckle-tracking echocardiography
英文摘要: Background(#br)Few data are available on cardiac morphology and function in children with heterozygous familial hypercholesterolemia (FH). Such patients represent a unique clinical model to assess the effect of pure hypercholesterolemia on cardiac morphology and function, excluding the effect of comorbidities. Speckle-tracking echocardiography, a relatively new echocardiographic modality, allows the assessment of myocardial deformation properties. The aim of this study was to define in children with FH the preclinical effects of isolated hypercholesterolemia on the cardiovascular system by examining left ventricular (LV) function using speckle-tracking echocardiography.(#br)Methods(#br)Ninety children (45 with FH and 45 controls; mean age, 11 ± 3 years) were prospectively...
全文获取路径: Elsevier  (合作)