Characterization of Meq proteins from field isolates of Marek’s disease virus in Japan
作者: Shiro MurataTomoyuki HashiguchiYuko HayashiYuki YamamotoAyumi Matsuyama-KatoSarah TakasakiMasayoshi IsezakiMisao OnumaSatoru KonnaiKazuhiko Ohashi
作者单位: 1Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita-18, Nishi-9, Kita-ku, Sapporo 060-0818, Japan
刊名: Infection, Genetics and Evolution, 2013, Vol.16 , pp.137-143
来源数据库: Elsevier Journal
DOI: 10.1016/j.meegid.2012.12.032
关键词: Marek’s disease virusMeqDistinct diversityTransactivation activity
英文摘要: Abstract(#br)Serotype 1 strains of Marek’s disease virus (MDV-1) cause malignant lymphomas in chickens (Marek’s disease; MD). Although MD has been controlled by vaccination, field isolates of MDV-1 have tended to increase in virulence and cause MD even in vaccinated chickens. Meq, a putative MDV-1 oncoprotein, resembles the Jun/Fos family of basic leucine zipper (bZIP) transcription factors and can regulate the expression of viral and cellular genes as a homodimer or as a heterodimer with a variety of bZIP family proteins. Sequencing analysis of some of the viral genes of various MDV-1 strains revealed a distinct diversity of and point mutations in Meq, which may contribute to changes in the transcriptional activities of Meq and, consequently, to increases in MDV-1 oncogenicity. However,...
全文获取路径: Elsevier  (合作)
影响因子:2.768 (2012)